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Separation of Chiral Compunds by High-Throughput Supercritical Fluid Chromatography (HT-SFC) |
 The JASCO HT-SFC system achieves high-throughput chromatographic analysis employing the AS-2059-SF Autosampler and automated column selection switching valve. It allows faster method development of multiple samples compared with normal HPLC or SFC. By using the CD-2095 Circular Dichroism detector and a chiral separation column, chiral compounds can be analyzed in a short period of time. Supercritical mobile phase offers a low pressure drop across the column so that a high flow rate can be applied, enabling shorter analysis time without sacrificing resolution.
Schematic FLow Diagram of the System
- Liquid carbon dioxide cylinder
- Modifier
- PU-2080-CO2 CO2 delivery pump
- PU-2080 delivery pump for modifier
- Solvent selector valve
- Stop valve
- Safty valve
- Mixer
- Accumulator
- AS-2059-SF autosampler
- HV-2080-03 column selector valve
- Chiral column
- CO-2060 column oven
- MD-2015 diode array detector with high pressure flow cell
- CD-2095 circular dichroism detector with high pressure flow cell
- BP-2080 automatic back pressure regulator
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